A novel regulatory network among LncRpa, CircRar1, MiR‑671 and apoptotic genes promotes lead‑induced neuronal cell apoptosis
research target：neuronal cell、lncRNA、circRNA、miRNA
Periodicals：Archives of Toxicology
IF：6.637
Cooperative Unit：Guangzhou Medical University
Time of publication：September，2016
Summary
Lead is a metal that has toxic effects on the developing nervous system. However, the mechanisms underlying lead-induced neurotoxicity are not well understood. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation, but few studies have examined the function of ncRNAs in lead-induced neurotoxicity. We addressed this in the present study by evaluating the functions of a long non-coding RNA (named lncRpa) and a circular RNA (named circRar1) in a mouse model of leadinduced neurotoxicity. High-throughput RNA sequencing showed that both lncRpa and circRar1 promoted neuronal apoptosis. We also found that lncRpa and circRar1 induced the upregulation of apoptosis-associated factors caspase8 and p38 at the mRNA and protein levels via modulation of their common target microRNA miR-671. This is the first report of a regulatory interaction among a lncRNA, circRNA, and miRNA mediating neuronal apoptosis in response to lead toxicity.
Partial results of cooperation
1.LncRpa and circRar1 promote apoptosis in lead-induced neurotoxicity
2.LncRpa and circRar1 interact directly with miR-671
3.LncRpa and circRar1 regulate miR-671 expression
References
Aruo Nan, Lijian Chen, Nan Zhang, et al. A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis[J]. 2016.
