Product introduction：
RIP is a technology for studying the binding of RNA and protein in cells. It is a powerful tool to understand the dynamic process of post-transcriptional regulatory networks. It can be applied to study miRNA regulatory targets, the interaction between RNA and RBPs, etc.
Use antibodies or epitope markers to capture endogenous RNA binding proteins in the nucleus or cytoplasm to prevent non-specific RNA binding.Immunoprecipitation separates the RNA binding protein and its bound RNA together, and the RNA sequence is identified by RIP-chip, RT-PCR or RIP-Seq.(This kit is for scientific research purposes only)
Technical process：
Product features：
1.Convenient, fast and easy to operate.
2.Provide optimized magnetic beads, suitable for precipitation of RNA-protein complexes.
3.High quality and good stability.
4.The result has a high repetition rate.
5.Simple operation, short time-consuming, objective and accurate results.
6.The first and exclusive product in China with independent intellectual property rights.
Instructions
Bes5101 RIP （12T、24T、40T）
Articles
【In 2023】
Article：From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism
Periodicals：Signal Transduction and Targeted Therapy
IF：39.3
Article：CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
Periodicals：Nature Communications
IF：16.600
Article：Tumor Cell Derived Lnc-FSD2-31:1 Contributes to Cancer-Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR-4736
Periodicals：Advanced Science
IF：15.100
Article：N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop
Periodicals：Advanced Science
IF：15.100
Article：ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein
Periodicals：Advanced Science
IF：15.100
Article：Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase
Periodicals：Emerging Microbes & Infections
IF：13.200
Article：Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception
Periodicals：PNAS
IF：11.100
Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy
Periodicals：International Journal of Biological Sciences
IF：10.750
Article：Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration
Periodicals：Clinical and Translational Medicine
IF：10.600
Article：Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer
Periodicals：Pharmacological Research
IF：10.334
Article：CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling
Periodicals：Translational Research
IF：10.17
Article：WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis
Periodicals：Cell Death and Disease
IF：9.697
Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
Periodicals：Cell Death and Disease
IF：9.696
Article：Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis
Periodicals：BMC Medicine
IF：9.300
Article： Lnc-ZEB2-19 Inhibits the Progression and Lenvatinib Resistance of Hepatocellular Carcinoma by Attenuating the NF-κB Signaling Pathway through the TRA2A/RSPH14 Axis
Periodicals：International Journal of Biological Sciences
IF：9.200
Article： N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway
Periodicals：Cell Death & Disease
IF：9.000
Article：CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification
Periodicals：Clinical and Translational Medicine
IF：8.533
Article：FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cance
Periodicals：Cell Communication and Signaling
IF：8.400
Article：Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p
Periodicals：International Journal of Nanomedicine
IF：7.033
Article： METTL3-mediated m6A methylation of C1qA regulates the Rituximab resistance of diffuse large B-cell lymphoma cells.
Periodicals：Cell Death Discovery
IF：7.000
Article：Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis
Periodicals：Cancers
IF：6.575
Article：circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep
Periodicals：International Journal of Molecular Sciences
IF：6.208
Article：lncRNA HCG11 suppresses cell proliferation in hormone receptorpositive breast cancer via SRSF1/β-catenin
Periodicals：Aging
IF：5.956
Article：circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization
Periodicals：iScience
IF：5.800
Article：Circular Intronic RNA circTTN Inhibits Host Gene Transcription and Myogenesis by Recruiting PURB Proteins to form Heterotypic Complexes
Periodicals：International Journal of Molecular Sciences
IF：5.600
Article：Overexpression of FTO inhibits excessive proliferation and promotes the apoptosis of human glomerular mesangial cells by alleviating FOXO6 m6A modification via YTHDF3-dependent mechanisms
Periodicals：Frontiers in Pharmacology
IF：5.5999
Article：Interaction of Teleost Fish TRPV4 with DEAD Box RNA Helicase 1 Regulates Iridovirus Replication
Periodicals：Journal of Virology
IF：5.3999
Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer
Periodicals：American Journal of Cancer Research
IF：5.300
Article：Pro-fbrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
Periodicals：European Journal of Medical Research
IF：4.981
Article：CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
Periodicals：Arthritis Research & Therapy
IF：4.900
Article：METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis
Periodicals：Epigenetics
IF：4.861
Article：LncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway
Periodicals：Epigenetics
IF：4.861
Article：eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation
Periodicals：Jounal of Biological Chemistry
IF：4.800
Article：IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation
Periodicals：Cancer Medicine
IF：4.711
Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.
Periodicals：Reproductive biology and endocrinology
IF：4.400
Article：RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression
Periodicals：Oncology Reports
IF：4.200
Article：YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation
Periodicals：Heliyon
IF：4.000
Article：LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
Periodicals：BMC Cancer
IF：3.800
【In 2022】
Periodicals：Molecular Therapy
IF：12.91
Article：STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
Periodicals：International Journal of Biological Sciences
IF：10.75
Article：Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis
Periodicals：Cell Death and Disease
IF：9.685
Article：Hotair promotes the migration and proliferation in ovarian cancer by miR‑222‑3p/CDK19 axis
Periodicals：Cellular and Molecular Life Sciences
IF：9.26
Article：Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer
Periodicals：Cancer Letters
IF：8.697
Article：circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3
Periodicals：Biomarker Research
IF：8.633
Article：circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma
Periodicals：Experimental Hematology & Oncology
IF：8.593
Article：YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis
Periodicals：Cell Death & Disease
IF：8.469
Article：circCRKL, a circRNA derived from CRKL,regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation
Periodicals：Journal of Translational Medicine
IF：8.439
Article：PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62
Periodicals：Cells
IF：7.666
Article：Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors
Periodicals：PLOS Pathogens
IF：7.455
Article：A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic infammatory microenvironment
Periodicals：Stem Cell Research & Therapy
IF：6.832
Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a
Periodicals：Bioengineered
IF：6.832
Article：FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2
Periodicals：Cancers
IF：6.575
Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Periodicals：Cancer Science
IF：6.518
Article：LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation
Periodicals：Molecular Medicine
IF：6.376
Article：Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome
Periodicals：Frontiers in Cellular Neuroscience
IF：6.146
Article：CircMYH9 increases KPNA2 mRNA stability to promote hepatocellular carcinoma progression in an EIF4A3-dependent manner
Periodicals：American journal of cancer research
IF：5.942
Article：SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells
Periodicals：Cellular & Molecular Biology Letters
IF：5.78
Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
Periodicals：Cell Communication and Signaling
IF：5.712
Article：CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer
Periodicals：Cell Death Discovery
IF：5.24
Article：EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway
Periodicals：Cell Death Discovery
IF：5.24
Article：Long noncoding RNA LINC00518 contributes to proliferation and metastasis in lung adenocarcinoma via the miR-335-3p/CTHRC1 Axis
Periodicals：Cell Death Discovery
IF：5.24
Article：Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p
Periodicals：Cell Death Discovery
IF：5.24
Article：CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway
Periodicals：Cell Death Discovery
IF：5.24
Article：IGF2BP3 enhances the mRNA stability of E2F3 by interacting with LINC00958 to promote endometrial carcinoma progression
Periodicals：Cell Death Discovery
IF：5.24
Article：LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia
Periodicals：Scientifc Reports
IF：4.996
Article：Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury
Periodicals：Central European Journal of Immunology
IF：4.39
Article：Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8
Periodicals：Thorac Cancer
IF：3.5
Article：LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis
Periodicals：Disease Markers
IF：3.464
Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a
Periodicals：Bioengineered
IF：3.269
【In 2021】
Article：NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1
Periodicals：Signal Transduction and Targeted Therapy
IF：13.493
Article：Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β
Periodicals：Clinical and Translational Medicine
IF：11.492
Article：LINC00473-modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid-induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation
Periodicals：Bioengineering & Translational Medicine
IF：10.711
Article：HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer
Periodicals：Molecular Therapy-Nucleic Acids
IF：8.886
Article：hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3
Periodicals：Molecular Therapy-Nucleic Acids
IF：8.886
Article：CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944
Periodicals：Cell Death & Disease
IF：8.469
Article：LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity
Periodicals：Cell Death & Disease
IF：8.469
Article：LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer
Periodicals：Cell Death & Disease
IF：8.469
Article：LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma
Periodicals：Cell Death & Disease
IF：8.469
Article：Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：7.038
Article：SAFA initiates innate immunity against cytoplasmic RNA virus SFTSV infection
Periodicals：PLOS Pathogens
IF：6.823
Article：Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription
Periodicals：Am J Cancer Res
IF：5.884
Article：RPL34-AS1–induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway
Periodicals：Cancer Science
IF：4.966
Article：Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7
Periodicals：Genes
IF：3.757
Article：Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance
Periodicals：Technology in Cancer Research & Treatment
IF：3.399
Article：A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells
Periodicals：Bioengineered
IF：3.268
【In 2020】
Article：LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling
Periodicals：Theranostics
IF：8.698
Article：Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation
Periodicals：Stem Cell Research & Therapy
IF：5.081
Article：Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1
Periodicals：Cancer Science
IF：4.985
Article：Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer
Periodicals：iScience
IF：4.447
Article：LINC00689 promotes prostate cancer progression via regulating miR-496/CTNNB1 to activate Wnt pathway
Periodicals：Cancer Cell International
IF：3.991
Article：CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p
Periodicals：OncoTargets and Therapy
IF：3.259
【In 2019】
Article：CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：7.038
Article：PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression
Periodicals：Cell Death & Disease
IF：6.28
Article：Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2
Periodicals：Clinical Epigenetics
IF：5.156
Article：CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression
Periodicals：Frontiers in Oncology
IF：4.137
【In 2017】
Article：LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1
Periodicals：Journal of Cellular and Molecular Medicine
IF：4.302
References:
