Product introduction：
RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A, m7G, m1A and m5C. RNA methylation may play an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifespan and degradation, and mediating circular RNA translation. Using MeRIP technology, it is possible to conduct a comprehensive study of the post-transcriptional methylation profile of RNA.(This kit is for scientific research purposes only)
MeRIP helps to study the chemical modification of nucleic acid and its molecular mechanism. RNA methylation affects gene expression at several levels:
1.Affect the stability of mRNA.
2.Affect the shearing of mRNA.
3.Affect the binding of RNA and protein.
4.Affect the production of miRNA and so on.
Therefore, meRIP helps solve biological problems such as cell differentiation, biological development, disease occurrence and development, and heat shock response.
Technical process：
Test results:
Product features：
1.Fast and time-saving.
2.Stable and reliable.
3.Fully equipped.
Instructions
Bes5204-1 m5C MeRIP (12T、40T)
Bes5204-2 m5C MeRIP（with anti-m5C antibody; 12T、40T）
Articles
Article：NSUN5 accelerates the progression of liver hepatocellular carcinoma by m5C-EFNA3-mediated glycolysis.
Periodicals：BMC Cancer
IF：3.400
Article：5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications.
Periodicals：Journal of Ovarian Research
IF：4.200
Article：CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway.
Periodicals：Journal of Advanced Research
IF：11.400
Article：NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.
Periodicals：Redox Biology
IF：10.700
Article：ALYREF-JunD-SLC7A5 axis promotes pancreatic ductal adenocarcinoma progression through epitranscriptome-metabolism reprogramming and immune evasion.
Periodicals：Cell death discovery
IF：6.100
