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ChIRP Kit

According to different research objects, ChIRP technology combines high-throughput sequencing (ChIRP-Seq) and mass spectrometry (ChIRP-MS) to study the genes and proteins that interact with target RNA.
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PRODUCT INFORMATION

Product introduction：
ChIRP is used in experiments to study the interaction between RNA and DNA, RNA and protein.According to different research objects, ChIRP technology combines high-throughput sequencing (ChIRP-Seq) and mass spectrometry (ChIRP-MS) to study the genes and proteins that interact with target RNA.(This kit is for scientific research purposes only)
ChIRP technology is to design a biotin probe set to specifically pull down the target RNA through base complementary pairing, and at the same time enrich the DNA, RNA or proteins (RBPs) that interact with it.Finally, the gene is subjected to high-throughput sequencing or PCR to obtain the downstream target gene that regulates RNA transcription regulation.At the same time, RBPs can carry out Western Blot verification or MS identification.
BersinbioTM ChIRP Kits include: ChIRP-DNA Kit, ChIRP-Protein Kit and ChIRP-DNA, Protein Kit.






Technical process：






Result example：






Product features：

1.The first domestic company to independently develop a ChIRP kit.
2.Leading detection methods, accurate results and good repeatability.
3.High sensitivity and low detection limit.
4.High sensitivity and high specificity.
5.Fast detection, easy operation, safe and convenient.

6.BersinbioTM has independent intellectual property rights.


Instructions


Bes5104-1 ChIRP-DNA

Bes5104-2 ChIRP-Protein

Bes5104-3 ChIRP-DNA、Protein


Articles

【In 2023】


Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy

Periodicals：International Journal of Biological Sciences

IF：9.200


Article：Long Non-Coding RNA BNIP3 Inhibited the Proliferation of Bovine Intramuscular Preadipocytes via Cell Cycle

Periodicals：International Journal of Molecular Sciences

IF：5.600


Article：Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription

Periodicals：Cancer Cell International

IF：5.800


【In 2022】


Article：5mC and  H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma

Periodicals：Biomarker Research

IF：11.100


Article：LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

Periodicals：Cell Death and Disease

IF：9.000


Article：LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation

Periodicals：Molecular Medicine

IF：5.700


【In 2021】


Article：Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β

Periodicals：Clinical and Translational Medicine

IF：10.600


Article：Upregulated LINC01667 Expression Is Correlated With Poor Prognosis in Hepatocellular Carcinoma

Periodicals：Frontiers in Oncology

IF：6.244


【In 2020】


Article：Long Noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis

Periodicals：Cancer Research

IF：11.200


Article：Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Periodicals：iScience

IF：4.447


【In 2019】


Article：Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Periodicals：Advanced Science

IF：17.521


【In 2017】


Article：LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1

Periodicals：Journal of Cellular and Molecular Medicine

IF：4.302