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m6A MeRIP Kit

RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A and m5C.
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PRODUCT INFORMATION

Product introduction:
        RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A and m5C.RNA methylation may play an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifespan and degradation, and mediating circular RNA translation.Using MeRIP technology, it is possible to conduct a comprehensive study of the post-transcriptional methylation profile of RNA.(This kit is for scientific research purposes only)
        MeRIP helps to study the chemical modification of nucleic acid and its molecular mechanism. RNA methylation affects gene expression at several levels:
1.Affect the stability of mRNA.
2.Affect the shearing of mRNA.
3.Affect the binding of RNA and protein.
4.Affect the production of miRNA and so on.
        Therefore, meRIP helps solve biological problems such as cell differentiation, biological development, disease occurrence and development, and heat shock response.



Technical process:


Test results:



Product features:

1.Fast and time-saving.
2.Stable and reliable.

3.Fully equipped.


Instructions


Bes5203-1 m6A MeRIP (12T,40T)

Bes5203-2 m6A MeRIP (with anti-m6A antibody 12T,40T)


Articles



【In 2025


ArticleM6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression. 

Periodicals:Molecular Cancer

IF:33.900


Periodicals:Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

IF:15.800


ArticleTargeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer. 

Periodicals:Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

IF:14.100


ArticleBetaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m6A/YTHDF1-mediated enhancement on ATG3 stability. 

Periodicals:Theranostics

IF:12.400


ArticleThe m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy. 

Periodicals:Theranostics

IF:12.400


ArticleAGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer.

Periodicals:Journal of experimental & clinical cancer research: CR

IF:11.400


ArticleZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.

Periodicals:Cell Death & Disease

IF:9.600


ArticleM6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer.

Periodicals:Cell Death & Disease

IF:9.600


ArticleYTHDC1 phase separation drives the nuclear export of m6A-modified lncNONMMUT062668.2 through the transport complex SRSF3-ALYREF-XPO5 to aggravate pulmonary fibrosis. 

Periodicals:Cell Death & Disease

IF:9.600


ArticleXIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1.

Periodicals:Cell Death & Disease

IF:9.600


Article SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.

Periodicals:Cellular & Molecular Biology Letters

IF:9.200


ArticleMETTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination. 

Periodicals:Clinical and Translational Medicine

IF:7.900


ArticleN6-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.

Periodicals:Clinical and Translational Medicine

IF:7.900


Article An exploration on the involvement of the methyltransferase like 3-m6A‑zinc finger MYM-type containing 1 axis in the progression of liver hepatocellular carcinoma. 

Periodicals:International Journal of Biological Macromolecules

IF:7.700


ArticlePleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability. 

Periodicals:Cellular and Molecular Life Sciences : CMLS

IF:6.200


ArticleHelicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling.

Periodicals:Cell death discovery

IF:6.100


ArticleMTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.

Periodicals:International Journal of Molecular Medicine

IF:5.700


ArticleMettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia-Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy.

Periodicals:Investigative Ophthalmology & Visual Scicence

IF:5.000


ArticleSuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon axis to promote autophagy in diabetic kidney disease.

Periodicals:Frontiers in Pharmacology

IF:4.800


ArticleGIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification.

Periodicals:Molecular Neurobiology

IF:4.600


ArticleAbnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation. 

Periodicals:International Journal of Oncology

IF:4.500


ArticleAQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway.

Periodicals:Journal of cellular and molecular medicine

IF:4.300


ArticleWilms' tumor 1-associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A-dependent manner. 

Periodicals:Cell Biology International

IF:3.300


ArticleMETTL3-mediated m6A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis. 

Periodicals:American Journal of Cancer Research

IF:2.900


【In 2024


ArticleExosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.

Periodicals:Molecular cancer

IF:27.700


ArticleNatural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA.

Periodicals:Acta Pharmaceutica Sinica. B

IF:14.700


ArticlecircCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models. 

Periodicals:Nature communications

IF:14.700


ArticleM6A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8+ T cells and phagocytosis of macrophages. 

Periodicals:Advanced Science

IF:14.300


ArticleRNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer. 

Periodicals:Journal of Advanced Research

IF:11.400


Article FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.

Periodicals:Redox biology

IF:10.700


ArticleBetaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner. 

Periodicals:Redox biology

IF:10.700


Articlem6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia.

Periodicals:Journal of Nanobiotechnology

IF:10.600


ArticleFTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis.

Periodicals:Experimental & Molecular Medicine

IF:9.500


ArticleNoncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions. 

Periodicals:Experimental & Molecular Medicine

IF:9.500


Article Focused ultrasound combined with miR-1208-equipped exosomes inhibits malignant progression of glioma.

Periodicals:British Journal of Cancer

IF:6.400


ArticleCircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension. 

PeriodicalsJournal of the American Heart Association

IF:5.000


ArticleGlycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer.

PeriodicalsJournal of Immunology

IF:4.400


ArticlePrognostic analysis of patients with gastric cancer based on N6-methyladenosine modification patterns and tumor microenvironment characterization. 

Periodicals:Frontiers in Pharmacology

IF:4.400


ArticleALKBH5-mediated upregulation of CPT1A promotes macrophage fatty acid metabolism and M2 macrophage polarization, facilitating malignant progression of colorectal cancer. 

Periodicals:Experimental Cell Research

IF:3.300


【In 2023


ArticleFTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and  functional recovery following stroke

PeriodicalsNature Communications

IF17.694


ArticleCircular RNA encoded MET variant promotes glioblastoma tumorigenesis.

PeriodicalsNature Communications

IF16.601


ArticleMETTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer

PeriodicalsCell Death and Disease

IF9.696


ArticleM6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy

PeriodicalsInternational Journal of Biological Sciences

IF:9.200


ArticleIGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer

Periodicals:American Journal of Cancer Research

IF:5.300


ArticleF-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner

PeriodicalsCancers

IF:5.200


ArticleRBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer

Periodicals:International Journal of Oncology

IF:5.200


ArticleMETTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6

Periodicals:Nutrition & Metabolism

IF:4.500


ArticleMETTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.

PeriodicalsReproductive biology and endocrinology

IF4.400


ArticleFLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas

Periodicals:Heliyon

IF4.000


【In 2022


ArticleSilencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia

PeriodicalsAdvanced Science

IF17.521


ArticleMETTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4

PeriodicalsLeukemia

IF12.883


ArticleALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription

PeriodicalsJournal of Experimental & Clinical Cancer Research

IF12.658


ArticleAKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA

PeriodicalsCell Death and Disease

IF9.685


ArticleM6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1

PeriodicalsCancer Science

IF6.518


ArticleThe m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic b Cells by Regulating MafA Expression

PeriodicalsFrontiers in Endocrinology

IF6.055


ArticleThe m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis

PeriodicalsInternational Journal of Molecular Sciences

IF5.924


ArticleMETTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma

PeriodicalsCell Communication and Signaling

IF5.712


ArticleN6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability

PeriodicalsCell Death Discovery

IF5.24


ArticleMethyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

PeriodicalsMolecular Pain

IF3.37


【In 2021


ArticleSaikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling

PeriodicalsTheranostics

IF8.578


ArticleLow Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA

PeriodicalsFrontiers in Cellular Neuroscience

IF5.505


【In 2019


Article:Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

PeriodicalsAdvanced Science

IF17.521