Product introduction：
RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A and m5C.
RNA methylation may play an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifespan and degradation, and mediating circular RNA translation.
Using MeRIP technology, it is possible to conduct a comprehensive study of the post-transcriptional methylation profile of RNA.(This kit is for scientific research purposes only)
MeRIP helps to study the chemical modification of nucleic acid and its molecular mechanism. RNA methylation affects gene expression at several levels:
1.Affect the stability of mRNA.
2.Affect the shearing of mRNA.
3.Affect the binding of RNA and protein.
4.Affect the production of miRNA and so on.
Therefore, meRIP helps solve biological problems such as cell differentiation, biological development, disease occurrence and development, and heat shock response.
Technical process：
Product features：
1.Fast and time-saving.
2.Stable and reliable.
3.Fully equipped.
Instructions
Bes5203-1 m6A MeRIP (12T、40T)
Bes5203-2 m6A MeRIP (with anti-m6A antibody；12T、40T)
Articles
【In 2023】
Article：FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
Periodicals：Nature Communications
IF：17.694
Article：Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Periodicals：Nature Communications
IF：16.601
Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
Periodicals：Cell Death and Disease
IF：9.696
Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy
Periodicals：International Journal of Biological Sciences
IF：9.200
Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer
Periodicals：American Journal of Cancer Research
IF：5.300
Article：F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner
Periodicals：Cancers
IF：5.200
Article：RBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer
Periodicals：International Journal of Oncology
IF：5.200
Article：METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6
Periodicals：Nutrition & Metabolism
IF：4.500
Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.
Periodicals：Reproductive biology and endocrinology
IF：4.400
Article：FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas
Periodicals：Heliyon
IF：4.000
【In 2022】
Article：Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia
Periodicals：Advanced Science
IF：17.521
Article：METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4
Periodicals：Leukemia
IF：12.883
Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Periodicals：Cell Death and Disease
IF：9.685
Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Periodicals：Cancer Science
IF：6.518
Article：The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic b Cells by Regulating MafA Expression
Periodicals：Frontiers in Endocrinology
IF：6.055
Article：The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis
Periodicals：International Journal of Molecular Sciences
IF：5.924
Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
Periodicals：Cell Communication and Signaling
IF：5.712
Article：N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
Periodicals：Cell Death Discovery
IF：5.24
Article：Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner
Periodicals：Molecular Pain
IF：3.37
【In 2021】
Article：Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling
Periodicals：Theranostics
IF：8.578
Article：Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA
Periodicals：Frontiers in Cellular Neuroscience
IF：5.505
【In 2019】
Article：Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family
Periodicals：Advanced Science
IF：17.521
