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MeRIP Kit

RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A and m5C.
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PRODUCT INFORMATION

Product introduction：
RNA methylation refers to the methylation modification phenomenon that occurs at different positions on the RNA molecule. The common methods of RNA post-transcriptional modification include m6A and m5C.
RNA methylation may play an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifespan and degradation, and mediating circular RNA translation.
Using MeRIP technology, it is possible to conduct a comprehensive study of the post-transcriptional methylation profile of RNA.(This kit is for scientific research purposes only)
MeRIP helps to study the chemical modification of nucleic acid and its molecular mechanism. RNA methylation affects gene expression at several levels:
1.Affect the stability of mRNA.
2.Affect the shearing of mRNA.
3.Affect the binding of RNA and protein.
4.Affect the production of miRNA and so on.
Therefore, meRIP helps solve biological problems such as cell differentiation, biological development, disease occurrence and development, and heat shock response.






Technical process：






Product features：

1.Fast and time-saving.
2.Stable and reliable.

3.Fully equipped.


Instructions


Bes5203-1 m6A MeRIP  

Bes5203-2 m6A MeRIP（with anti-m6A antibody）


Articles


【In 2023】


Article：FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and  functional recovery following stroke

Periodicals：Nature Communications

IF：17.694


Article：Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.

Periodicals：Nature Communications

IF：16.601


Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer

Periodicals：Cell Death and Disease

IF：9.696


Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy

Periodicals：International Journal of Biological Sciences

IF：9.200


Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer

Periodicals：American Journal of Cancer Research

IF：5.300


Article：F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner

Periodicals：Cancers

IF：5.200


Article：RBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer

Periodicals：International Journal of Oncology

IF：5.200


Article：METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6

Periodicals：Nutrition & Metabolism

IF：4.500


Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.

Periodicals：Reproductive biology and endocrinology

IF：4.400


Article：FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas

Periodicals：Heliyon

IF：4.000


【In 2022】


Article：Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia

Periodicals：Advanced Science

IF：17.521


Article：METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4

Periodicals：Leukemia

IF：12.883


Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription

Periodicals：Journal of Experimental & Clinical Cancer Research

IF：12.658


Article：AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA

Periodicals：Cell Death and Disease

IF：9.685


Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1

Periodicals：Cancer Science

IF：6.518


Article：The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic b Cells by Regulating MafA Expression

Periodicals：Frontiers in Endocrinology

IF：6.055


Article：The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis

Periodicals：International Journal of Molecular Sciences

IF：5.924


Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma

Periodicals：Cell Communication and Signaling

IF：5.712


Article：N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability

Periodicals：Cell Death Discovery

IF：5.24


Article：Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Periodicals：Molecular Pain

IF：3.37


【In 2021】


Article：Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling

Periodicals：Theranostics

IF：8.578


Article：Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA

Periodicals：Frontiers in Cellular Neuroscience

IF：5.505


【In 2019】


Article：Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Periodicals：Advanced Science

IF：17.521