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ChIP Kit

ChIP is currently the best method to determine the genomic region that binds to a specific protein, or to determine the protein that binds to a specific genomic region.
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PRODUCT INFORMATION

Product introduction:
ChIP is an ideal technology for studying the interaction between proteins and DNA in the body. It is currently the best method to determine the genomic region that binds to a specific protein, or to determine the protein that binds to a specific genomic region.ChIP combined with other experimental techniques can be used for detection of different purposes.The ChIP-Seq method is to purify and construct a library of specifically enriched DNA fragments bound by the target protein, and then perform high-throughput sequencing on the enriched DNA fragments.(This kit is for scientific research purposes only)
In the state of living cells, the protein and DNA in the cell are cross-linked, and ultrasound cuts it randomly into small fragments of chromatin within a certain length.Then immunoprecipitate the protein-DNA complex with the target protein-specific antibody to specifically enrich the DNA fragments bound by the target protein.

 





Technical process:







Result example:







Product features:

1.Efficient and specific enrichment efficiency; the enrichment ratio of positive and negative controls is >120, and each ChIP reaction only requires 100,000 cells.
2.It has strong compatibility with downstream analysis methods. Compatible downstream analysis methods include: RT-qPCR, gene chip and High-Throughput Sequencing.

3.Excellent technical service team, technical service is efficient, comprehensive and rapid, and can promptly help customers solve the problems encountered in the experiment as soon as possible.


Instructions


Bes5001 ChIP(for animal)

Bes5002 ChIP(for plant)


Article


【In 2023


ArticleActivation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis

Periodicals:Science Advances

IF:13.600


Article:Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis

PeriodicalsInternational Journal of Biological Sciences

IF:9.200


ArticleIdentification of a RAD51B enhancer variant for susceptibility and progression to glioma

Periodicals:Cancer Cell International

IF:5.800


ArticleNucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription

Periodicals:Cancer Science

IF:5.700


ArticleLincRNA00612 inhibits apoptosis and  inflammation in LPS-induced BEAS-2B cells via enhancing interaction between p-STAT3 and A2M promoter

PeriodicalsPeerJ

IF:2.700


【In 2022


Article:STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway

PeriodicalsSignal Transduction and Targeted Therapy

IF39.300


ArticleN6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer

PeriodicalsNature Communications

IF16.600


ArticleDual immunological and  proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1FGL1MYH9 axis

PeriodicalsFrontiers in Immunology

IF:7.300


ArticleInteraction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors

PeriodicalsPLOS Pathogens

IF:6.700


ArticleSp1 S-Sulfhydration Induced by Hydrogen Sulfide Inhibits Inflammation via HDAC6/MyD88/NF-κB Signaling Pathway in Adjuvant-Induced Arthritis

PeriodicalsAntioxidants

IF6.313


ArticleKnockdown of YY1 Inhibits XIST Expression and Enhances Cloned Pig Embryo Development

PeriodicalsInternational Journal of Molecular Sciences

IF6.208


ArticleARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression

PeriodicalsJournal of Cellular and Molecular Medicine

IF5.295


【In 2021


ArticleLoss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

PeriodicalsScience Advances

IF13.600


ArticleLncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

PeriodicalsCell Death & Disease

IF:9.000


ArticleNAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt/β-catenin signaling pathway in rheumatoid arthritis

PeriodicalsClinical and Translational Medicine

IF7.919


ArticleAn insertion variant of MGMT disrupts a STAT1 binding site and  confers susceptibility to glioma

PeriodicalsCancer Cell International

IF5.722


【In 2020


ArticleSLC2A3 promotes macrophage infltration by glycolysis reprogramming in gastric cancer

PeriodicalsCancer Cell International

IF4.175


【In 2019


ArticleNrf2-regulated miR-380-3p blocks the translation of Sp3 protein and its mediation of paraquat-induced toxicity in mouse neuroblastoma N2a cells

PeriodicalsToxicological Sciences

IF3.829


ArticleShortened nuclear matrix attachment regions are sufficient for replication and maintenance of episomes in mammalian cells

PeriodicalsMolecular Biology of the Cell

IF3.791


ArticleGenetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant

PeriodicalsCellular and Molecular Neurobiology

IF3.606


【In 2018


ArticleRIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression

PeriodicalsJournal of Experimental & Clinical Cancer Research

IF7.067


【In 2017


ArticleLncRNA PLAC2 down-regulates RPL36 expression and  blocks cell cycle progression in glioma through a mechanism involving STAT1

PeriodicalsJournal of Cellular and Molecular Medicine

IF4.302


【In 2015


ArticleTranscriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells

PeriodicalsNeuro-Oncology

IF9.384